Rookie Profile: Isaac Guerendo, Running Back, San Francisco 49ers
Welcome to the Rookie Profile: Isaac Guerendo, a Running Back from Clayton, IL who attended Avon High School. Guerendo was a 3-star recruit and attended Louisville.
Over the first three seasons of Guerendo’s collegiate career, he played only 11 games for the University of Wisconsin. During that span, he rushed for 197 yards and one touchdown while also catching 3 passes for 8 yards.
His best season at Wisconsin came in his final season there in 2022. He appeared in 12 games and rushed for 385 yards and 5 touchdowns. In addition, he chipped in with 17 catches for 115 yards and 1 receiving touchdown.
Guerendo transferred to Louisville for the 2023 season where he was the full-time starter and appeared in 14 games. He rushed for 810 yards and 11 touchdowns, both career highs. He also added in 22 receptions for 234 yards, also career highs.
It’s interesting to note that the unknown Guerendo exploded onto the season at the 2024 NFL Scouting Combine where he posted the fastest 40-yard Dash time of all the running backs.
Measurables
Draft Capital & Landing Spot
Draft Capital- Undrafted Free Agent Signing
- Guerendo went undrafted which is never a good sign, but at least he managed to sign onto a team with a history of burning through running backs. While his fantasy value is certainly minimal, he falls firmly into the watch list category for now.
Landing Spot- San Francisco 49ers
- The 49ers are not a great spot in either the short-term or long-term. Christian McCaffrey just signed an extension and as long as he is healthy, no other running back is getting on the field.
- The 49ers burn through running backs pretty often, and that’s Guerendo’s only path to relevance, an injury.
Team Depth Chart
Expected Role: Developmental Running Back
Depth Chart via Fantasy Pros
Fantasy Impact
There is no fantasy impact. He is a watch-and-see player and a desperation handcuff if you roster McCaffrey and are unable to draft his other handcuffs.
For now, put him on your watch list and monitor him if you are a CMC owner. That’s the extent of his fantasy relevance.
Check out our 2024 Rookie Rankings Page for a full breakdown of this rookie class.
